Hemp seed meal is the by-product of the oil extracted from hemp seed, with the protein content of about 50% and the oil content of about 5%. Compared with hemp seed, it has the characteristics of high protein and low fat. At the same time, the process of extracting oil by pressing makes hemp seed meal have a unique aroma, which can be used as an additive of meal replacement biscuits. The pressed hemp seed meal 1 and pressed hemp seed meal 2 produced by different oil factories are selected to prepare meal replacement biscuits. Through single factor experiment and orthogonal experiment, according to the sensory score, it is determined that when adding 6 g pressed hemp seed meal 1, 20 g butter, 13 g xylitol, 0.2 g sodium bicarbonate or 8 g pressed hemp seed meal 2, 25 g butter, 13 g xylitol and 0.2 g sodium bicarbonate into 100 g low-gluten flour, the taste and morphology of the biscuits are the best. The in vitro digestibility of biscuits with pressed hemp seed meal 1 and pressed hemp seed meal 2 is both higher than 80 %, which is not significantly different from that of biscuits with the same proportion of soybean meal. At the same time, the in vitro digestion products have the ability to scavenge 1, l-diphenyl-2-picrylhydrazyl CDPPH) free radicals.