Provided is an agent for preventing or ameliorating neuropathy caused by decreased nerve function due to nerve damage or diabetic neuropathy. The agent for preventing or ameliorating neuropathy is obtained by combining one or more lactone compounds represented by formulae (1a) and (1b) and one or more substances from among hydroxybenzoic acid compounds represented by formula (2) and salts thereof. (In the formulas, R1 represents a hydrogen atom or a hydroxy group and R2 represents a hydrogen atom or a methyl group).

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