To provide a novel MMP expression inhibitor that effectively inhibits MMP expression, and exhibits excellent inhibitory effect on various diseases caused by MMP overexpression.SOLUTION: An alanine and a proline according to the present invention have excellent MMP expression inhibitory action. Therefore, inhibiting MMP expression makes it possible to inhibit diseases such as arthritis, osteoporosis arteriosclerosis, hepatic cirrhosis, pulmonary fibrosis, periodontitis, corneal tumor, skin tumor, cancer invasion/metastasis, skin wrinkling/sagging.SELECTED DRAWING: None

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