A nutritional supplement contains 50 percent to 80 percent by weight of trimethylglycine; 5 percent to 30 percent by weight of L-a-glycerophosphorylcholine; 5 percent to 15 percent by weight of caffeine; and 5 percent to 10 percent by weight of an ingredient selected from the group consisting of an L-amino acid, creatyl-L-leucine, Corynanthe yohimbe bark extract, theacrine, and mixtures thereof. The nutritional supplement is useful for enhancing energy, mental acuity, cognitive performance, and reaction time in a subject in need thereof.

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