An object is to provide a material having an excellent stem cell growth promoting action. It has been found that Mannentinus obtained by culturing Mannentinus in a medium containing a specific amount of a babgas in a process of culturing Mannentinus has remarkably excellent stem cell growth promoting action compared to conventional Mannentinus. The external preparation for skin, pharmaceuticals, and food products containing the extract of Mannentinus as an active ingredient can largely contribute to the fields of regenerative medicine, regenerative cosmetic, and the like, and are extremely effective for the maintenance of tissue homeostasis and the repair and regeneration of damaged tissue. None

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