An object is to simply estimate an environmental temperature from a meta-genome configuration. An information processing system includes an acquisition unit that acquires relationship information in which configuration information indicating a configuration of a metago acquired from a sample containing a microbial cluster composed of a plurality of types of microorganisms and environmental temperature information indicating a temperature of an environment where the microbial cluster lives are associated in advance, An estimation unit that estimates the other information on the basis of the relationship information, and an output unit that outputs the estimated other information. Figure 1

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