Previous research by our team has shown that Fagopyrum cymosum capsules may exert a regulatory effect on intestinal inflammation and immunity through their heat clearing and detoxification effects, and have the potential to become a new approach for treating colitis. In this study, an investigation was conducted to determine whether Fagopyrum cymosum capsules could exert a protective effect on Dextran sulfate sodium (DSS) induced ulcerative colitis rats and to explore its potential mechanisms. The results showed that Fagopyrum cymosum capsules effectively alleviated symptoms such as colon length, weight loss, fecal viscosity, fecal blood and diarrhea in colitis rats. In addition, it up-regulated the protein expression of Occludin, Claudin-1, and Zona occludens-1 (ZO-1), thereby minimizing histological damage and restoring the colonic mucosal barrier. Fagopyrum cymosum capsules suppressed the levels of pro-inflammatory cytokines such as IL-6, IL-1β and IFN- γ in colon tissue and also elevated the production of anti-inflammatory cytokine IL-4....

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