A culture of a three-dimensional tissue with a built-in lymphatic network is provided. A three-dimensional tissue culture with a lymphatic network, comprising: A mesenchymal stem cell; and lymphatic endothelial cells, wherein the three-dimensional tissue comprising the mesenchymal stem cells has a structure that incorporates a lymphatic network-like structure comprising the lymphatic endothelial cells, Wherein the mesenchymal stem cells are coated with an extracellular matrix. None

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