Provided is an aminoacyl-tRNA synthetase that can apply a tyrosine-targeted genetic code extension technique to a kuko. Provided is a kombyx kombyx which can produce a non-natural tyrosine-containing protein. An aminoacyl-tRNA synthetase comprising a predetermined amino acid sequence, such as the amino acid sequence shown in any of SEQ ID NOS: 1-57-4 and having an activity of binding a desired unnatural amino acid to tyrosine-specific tRNA. The non-natural amino acid is preferably a tyrosine analogue. The komi expresses the aminoacyl-tRNA synthetase in the silk gland. None

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