An object of the present invention is to provide a pharmaceutical composition for use in the prevention or treatment of vascular disorders, particularly severe limb ischemia. (A) at least one microRNA selected from miR-709, miR-1247-3p, miR-671-5p, miR-8110, miR-765, and miR-3678-3p; Or a precursor thereof; or (b) at least one microRNA selected from miR-709, miR-1247-3p, miR-671-5p, miR-8110, miR-765, and miR-3678-3p, Or a precursor thereof. Figure 1

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