[Problem] to elucidate an active ingredient having an excellent CD39 expression-promoting effect contained in Darmazus, and to provide a CD39 expression-promoting agent containing the active ingredient. [Solution] the CD39 expression promoter in the skin Langerhans cell of the present invention contains a compound having a bicyclic diterpene skeleton, a salt thereof, or a solvate thereof as an active ingredient, wherein the compound having the bicyclic diterpene skeleton is selected from the group consisting of sclareol, Sclareol glycosides and isomalonol glycosides. Selected drawing: None
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