[Problem] To provide a immunoglobulin-binding protein which has improved chemical stability, particularly stability with respect to alkalis, an immunoglobulin-binding protein which enables antibody elution in mild pH conditions, and an adsorbent on which the protein is immobilized. [Solution] The present invention solves the above problem by including an amino acid sequence of an immunoglobulin binding domain of a protein L derived from bacteria of the genus Finegoldia, wherein in the amino acid sequence, an amino acid residue of a specific site in the domain is substituted with another specific amino acid residue, so that antibody elution properties or stability with respect to alkalis is improved.
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Patent| August 16 2023
4560, Kaisei-cho, Shunan-shi, Yamaguchi 7468501 ?7468501 JP
Journal: PCT International Patent Application
Citation: PCT International Patent Application (2023)
HASEMI TAKATOSHI, IWASE AKIHIRO, ENDO SATOSHI, TANAKA TORU; IMMUNOGLOBULIN-BINDING PROTEIN. IFIS Food and Health Sciences Database 2023; doi:
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