[Problem] To provide a immunoglobulin-binding protein which has improved chemical stability, particularly stability with respect to alkalis, an immunoglobulin-binding protein which enables antibody elution in mild pH conditions, and an adsorbent on which the protein is immobilized. [Solution] The present invention solves the above problem by including an amino acid sequence of an immunoglobulin binding domain of a protein L derived from bacteria of the genus Finegoldia, wherein in the amino acid sequence, an amino acid residue of a specific site in the domain is substituted with another specific amino acid residue, so that antibody elution properties or stability with respect to alkalis is improved.

Keywords
YEASTS FUNGI CELLS YEASTS FUNGI VECTORS GM MICROORGANISMS GMO GENE EXPRESSION GENE TRANSFER GENES MONOCLONAL ANTIBODIES MICROBIAL PROTEINS PROKARYOTES BACTERIA ESCHERICHIA COLI PROTEINS IMMUNOGLOBULINS AMINO ACIDS ORGANIC COMPOUNDS MONOCLONAL ANTIBODIES VECTORS GM MICROORGANISMS GMO CELLS GENE EXPRESSION GENE TRANSFER GENES RECOMBINEERING FERMENTATION PRODUCTS GENETIC ENGINEERING IMMOBILIZATION
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