The purpose of the present invention is to provide: an agent for activating or suppressing a cell-to-cell communication through a functional protein, which can modify a cell-to-cell communication; an antibody or an aptamer which can be used in the agent; a method for screening for the agent; a fusion protein capable of modifying an exosome; a nucleic acid encoding the fusion protein; a recombinant vector carrying the nucleic acid; a host cell transformed with the recombinant vector; an exosome function modulator comprising the fusion protein or the nucleic acid; and an exosome comprising the fusion protein. An agent for activating or suppressing a cell-to-cell communication through a functional protein, the agent comprising a substance capable of increasing or decreasing the expression of UBL3 gene or UBL3 protein or a substance capable of enhancing or inhibiting the activity of UBL3 protein. A method for screening for the agent by employing, as...

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