Calcium carbonate (CaCO3) has long been used as a delivery system owing to its wide availability, biocompatibility, and degradability. However, it often suffers from many challenges toward rapid dissolution at stomach acid environment, low retention ability, and lack of sustained release. Many of these issues can be addressed by modifying the CaCO3 particles or integrating them with other encapsulation systems, generating advanced CaCO3-derived systems. This review article presents a recent progress (2015-2022) in the utilization of CaCO3 particles in the exploration of various advanced delivery systems, including polymer-doped CaCO3, surface-coated CaCO3, CaCO3-stabilized Pickering emulsions, CaCO3-in-hydrogels, and liposomal CaCO3. Some emerging systems templated on CaCO3 sacrificial cores, such as hollow capsules, matrix-type capsules, and core-shell capsules, are also reviewed. A brief description of each system is given, and then their formation, structure, and properties...
Advanced CaCO3-derived delivery systems for bioactive compounds.
S. M. Jafari, Department of Food Materials and Process Design Engineering, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran. E-mail firstname.lastname@example.org
Chen Tan, Dima, C., Meigui Huang, Assadpour, E., Jing Wang, Baoguo Sun, Kharazmi, M. S., Jafari, S. M.; Advanced CaCO3-derived delivery systems for bioactive compounds.. IFIS Food and Health Sciences Database 2023; doi:
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