Globally Vibrio cholerae antibiotics resistance to RNA and DNA effective antibiotics: a systematic review and meta-analysis.

Background. Vibrio cholerae (V. cholerae) is a facultative pathogen that colonizes the small intestine and produces cholerae toxin as the primary virulence factor that causes cholera and fatal diarrhea in humans. In recent decades, V. cholerae has emerged as a notorious multidrug-resistant enteric pathogen. This meta-analysis estimated the pooled proportion of V. cholerae antimicrobial resistance against RNA and DNA effective antibiotics. Method A systematic search was performed for relevant literature until 05 June 2021 in PubMed, Scopus, Embase, and Web of Science databases. Freeman-Tukey double arcsine transformation was performed to estimate weighted pooled resistance (WPR). Results. The meta-analysis were included 164 articles. The WPR of V. cholerae were as follows 76% [67,84] to furazolidone, 65% [29,94] to nitrofurantoin, 55% [44,66] to nalidixic acid, 10% [2,23] to rifampicin, 4% (0,12) to novobiocin, 4% [2,6] to norfloxacin, 3% [1,4] to ciprofloxacin, 1% (0,3) to sparofloxacin, 0% (0,3) to levofloxacin, 0%...