The probiotic E. Coli Nissle 1917 (EcN) plays an important role in regulating the microbial components of the gut and preventing inflammation of the gastrointestinal tract. Currently, the long-term use of antibiotics for the treatment of lethal white diarrhea in chicks caused by Salmonella has led to increased morbidity and mutation rates. Therefore, we want to use EcN as an antibiotic alternative as an alternative approach to prevent Salmonella-induced white diarrhea in chickens. To date, there are no reports of EcN being used for the prevention and control of Salmonella pullorum (S. pullorum) in chickens. In vitro, pretreatment with EcN significantly decreased the cellular invasion of S. pullorum CVCC533 in a chicken fibroblast (DF-1) cell model. Then, 0-day-old egg-laying chickens were orally inoculated with EcN at a dose of 109 CFU/100 μL at either Day 1 (EcN1) or both Day 1 and Day 4 (EcN2)....

Keywords
SEQUENCING CHICKEN LIVERS CHICKENS PILI MORTALITY DIARRHOEA INFECTION FOOD SAFETY ANIMAL FOODS SPLEENS INTESTINES BODY WT. SALMONELLA PULLORUM COLONIZATION ESCHERICHIA COLI PILI GASTROINTESTINAL MICROFLORA INVASION
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