Salmonella spp. poses a great threat to the livestock, food safety and public health. A recombinant Swinepox virus expressing a protective antigen sseB was constructed by homologous recombination to develop a vaccine against Salmonella infection. The rSPV-sseB was verified using PCR, Western blot and indirect immunofluorescence assay. The immune responses and protective efficacy of rSPV-sseB were assessed in piglets. Forty piglets were immunized with rSPV-sseB, inactive Salmonella vaccine, wild-type SPV (wtSPV), or PBS. The results showed that the level of the sseB-specific antibody of the rSPV-sseB-vaccinated piglets was significantly higher at all time points post-vaccination than those of the inactivated Salmonella vaccine (P < 0.05), wtSPV (P < 0.001) or mock treated piglets (P < 0.001). The IL-4 and IFN-γ in the rSPV-sseB group were significantly higher than the other three groups at all post-infection time points. RSPV-sseB provided piglets with strong protection against the challenge of...
The recombinant swinepox virus expressing sseB could provide piglets with strong protection against Salmonella typhimurium challenge.
Xisha Lin, School of Biological Science and Food Engineering, Chuzhou University, Chuzhou, 239000, China. E-mail firstname.lastname@example.org
Lin Ji, Xisha Lin, Kenan Yuan, Yue Li, Ambreen Leghari, Bingbing Yuan, Huixing Lin; The recombinant swinepox virus expressing sseB could provide piglets with strong protection against Salmonella typhimurium challenge.. IFIS Food and Health Sciences Database 2023; doi:
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