Provided is a nucleic acid structure that enhances an antigen-specific immune response. The nucleic acid structure includes a polynucleotide that codes for any SNARE protein selected from the group consisting of VAMP7, GOSR2, STX10, STX18, BNIP1, STX7, VTI1A, STX16, STX5, GOSR1, STX8, STX12, VAMP8 and SEC22B, and a polynucleotide that codes for an antigen.

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