Provided is a technique for determining whether or not a subject is capable of serializing a systemic inflammatory-responsive microvascular endothelial disease (SIME) condition. A method of treating a disease associated with systemic inflammatory microvascular disease, the method comprising a specific binding agent for an IQ Motif Containting GTPase Activating Protein 1 (IQGAP1) protein and being used to measure the IQGAP1 protein in a blood sample from a subject, wherein significantly greater abundance of the IQGAP1 protein in the blood sample than a control indicates a condition associated with systemic inflammatory microvascular disease, A kit for diagnosing SIRME pathology. None
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