A highly safe Tie2 activator having an excellent Tie2 activating action, a highly safe Tie2 activator having an excellent blood vessel and/or lymphatic vessel stabilizing action and a highly safe blood vessel and/or lymphatic vessel stabilizing action, and a highly safe blood vessel and/or lymphatic vessel maturation action, Provided are highly safe blood vessel and/or lymphatic vessel maturation agents. A Tie 2 activator comprising a compound represented by structural formula (1) or the like. JPEG2023021487000038.jpg61130
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