Provided are novel microparticles that can control expression of proteins and/or genes associated with NK cell activation. Microparticles comprising a miRNA associated with NK cell activation and derived from a culture supernatant of dental pulp-derived stem cells or a culture supernatant of fat-derived stem cells; an NK cell activator; a method for culturing NK cells; a method for producing activated NK cells; and a method for activating NK cells. Figure 2

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