Supplementation with goat meat extract improves exercise performance, reduces physiological fatigue, and modulates gut microbiota in mice.

The goat meat extract (GME) is novel nutritional supplement and may be used to enhance exercise performance or prevent physiological fatigue on elder or weak person. The present study evaluated the potential beneficial effects of GME on exercise performance, anti-fatigue potency, and changes in microbiota composition. Our results showed that 2X-to 3X-GME supplementation significantly improved forelimb grip strength and swimming time-to-exhaustion. Serum levels of lactate, AST and LDH were decreased as well as glycogen content of liver was higher in the 3X-GME group. The distinguished clusters of gut microbiota were dependent on different concentrations of the GME supplement. The gut microbiota including Eubacterium oxidoreducens, Neglecta timonensis, Raoultibacter timonensis, and Robinsoniella peoriensis were strongly correlated with GME supplementation. In summary, GME supplementation for could improve exercise endurance and did not cause any physiological or histopathological damage. These benefits potential might correlated with the gut microbiota composition alteration. All...