Promoting effect of sea cucumber peptides on acetic acid-induced gastric ulcer healing in rats.

The effect of sea cucumber peptides (SCP) on the wound healing of rats was investigated by establishing an excisional skin wound model in rats. Then, the anti-gastric ulcer was evaluated using an animal model of ulcerative lesions induced by acetic acid, and then the mice were gavaged with different doses of SCP (0.5 mg/g and 2 mg/g). The effect of antioxidant factors, inflammation cytokines, and defensive factor levels in the gastric tissue homogenate of rats were analyzed for the bioactivities of SCP. The results showed that the wound healing rate of the SCP group was significantly higher than control group from the 2^th day after modeling and the wound had almost healed up after 12 days. Compared to the model group, the ulcer area of SCP-treated rats was significantly decreased, and the inhibition rate reached 41.45% and 60.41 %. The pathological findings suggested that mucosa regeneration, and inflammatory cell...