Background. Knowledge is limited about the relationship between clinical reactivity to foods through breastfeeding and long-term food allergy outcomes. We explored parent-perceived symptoms of food allergy via breastfeeding and the association with future tolerance. Methods. Subjects identified from the Chicago Food Allergy Study (2005-2011) were categorized by parent-reported reactions to maternally ingested foods via breastfeeding (50/898 peanut-allergic, 69/620 egg-allergic, and 153/589 milk-allergic). The primary outcome was tolerance [passed oral food challenge (OFC) or consumption of previously implicated food]. Secondary outcomes included severe reactions (anaphylaxis and/or cardiovascular/respiratory symptoms) and additional concomitant food allergies. Univariate chi-square analyses were performed to assess for association between variables, followed by logistic regression models. Results. Of the 50 subjects with parent-reported peanut-associated symptoms with breastfeeding, none gained tolerance. There were no significant associations between parent-reported breastfeeding symptoms and development of tolerance for egg and milk (egg: OR 0.46, 95% CI 0.21-1.01, p = 0.053; milk: OR...
Exploration of parent-reported food allergy symptoms via breastmilk exposures and likelihood to develop tolerance.
Rajesh Kumar, Division of Allergy and Immunology, Ann and Robert H. Lurie Children's Hospital of Chicago, 225 E Chicago Ave, Box 60, Chicago, IL, 60613, USA. E-mail email@example.com
Lang, A., Shrey Patel, Rychlik, K., Caruso, D., Xiaobin Wang, Pongracic, J. A., Rajesh Kumar; Exploration of parent-reported food allergy symptoms via breastmilk exposures and likelihood to develop tolerance.. IFIS Food and Health Sciences Database 2023; doi:
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