Antitumor effect of lactogenic compound probiotics on CT-26 tumor-bearing mice.

To study the anti-tumor effect of four compound probiotics derived from camel's milk on CT-26 tumor-bearing mice, colon cancer CT-26 cells were inoculated into the axilla of BALB/C mice to establish CT-26 solid tumor model. After tumor formation, the mice were randomly divided into model group, low-dose compound probiotics group, high-dose compound probiotics group and 5-fluorouracil group. Normal BALB/C mice were also taken as normal control, with 10 mice in each group. After 21 days of continuous administration, the weight of tumor, thymus and spleen was weighed, and the tumor inhibition rate, spleen coefficient and thymus coefficient were calculated. The pathological changes of tumor tissues were observed by HE staining, the proportion of T cell subsets in tumor bearing mice was analyzed by FCM, and the invasion density of Foxp³⁺ Tregs in tumor tissues was observed by immunofluorescence. Serum LEVELS of IL-2, IL-10 and IFN-γ in tumor-bearing mice were...