Mitigation of food pathogens such as Salmonella continues to be a focus in poultry production, whether on shell eggs or meat products. No single approach is fully able to eliminate the risk, but rather comprehensive programs are used in a multifaceted approach. Targeted in-feed additives are a component of a food safety program and may help to reduce Salmonella infection. This study was aimed to evaluate the efficacy of a probiotic and prebiotic combination feed-additive product (Fulfill Plus) to reduce Salmonella Enteritidis (S.E.) infection in layer hens. One-hundred and forty-four (144) 1-day-old Hy-line pullets were raised on new litter until 10 wk of age when they were moved into individual cages. There were 3 treatments, 1) Untreated 2) probiotic and prebiotic combination given D 0 to termination, and 3) probiotic and prebiotic combination given Wk 10 to termination. At 17 weeks-of-age each bird was orally challenged with 3 × 10...

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