Artemisinin-hydroxychloroquine sulfate tablets (AH) are considered a relatively inexpensive and novel combination therapy for treating all forms of malaria, especially aminoquinoline drugs-resistant strains of P. falciparum. We aim to carry out acute and subacute oral toxicity studies in rats to acquire preclinical data on the safety of AH. Acute toxicity was evaluated in Sprague-Dawley (SD) rats at a single dose of 1980, 2970, 4450, 6670, and 10000mg/kg. A 14-days subacute toxicity was assessed in SD rats at doses of 0, 146, 219, 328, and 429mg/kg. The median lethal dose (LD50) of acute oral administration of AH in rats is found to be 3119mg/kg, and toxic symptoms include decreased spontaneous activity, dyspnea, bristling, soft feces, spasticity, and convulsion. Repeated doses of AH have toxic effects on the nervous system, skin, blood system, liver, kidney, and spleen in rats. The main toxic reactions include epilation, emaciation, mental irritability, decreased...
Acute and subacute oral toxicity of artemisinin-hydroxychloroquine sulfate tablets in rats.
Li Ru, Guangzhou University of Chinese Medicine, No.12, Airport Road, Guangzhou City, China. E-mail firstname.lastname@example.org
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Xiaobo Li, Xingcheng Liao, Xiufang Yan, Yueming Yuan, Zheng Yuan, Ruidong Liu, Zhiyong Xu, Qi Wang, Qin Xu, Li Ru, Jianping Song; Acute and subacute oral toxicity of artemisinin-hydroxychloroquine sulfate tablets in rats.. IFIS Food and Health Sciences Database 2022; doi:
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