Background. Specific IgE to Ara h 2 is a diagnostic test for peanut allergy which may reduce the need for double-blind placebo-controlled food challenges (DBPCFC); however, guidance for using Ara h 2 in place of DBPCFCs has not been validated. Objective. To prospectively evaluate 1) diagnostic accuracy of previously published Ara h 2 cut-off levels to diagnose peanut allergy in children and 2) costs. Methods. A consecutive series of 150 children age 3.5 to 18 years was evaluated in secondary and tertiary settings in the Netherlands. SIgE to Ara h 2 was the index test, and oral peanut ingestion was the reference test. Oral peanut ingestion was home or supervised introduction for Ara h 2 â‰¤ 0.1, DBPCFC for 0.1-5.0 and open food challenge for â‰¥ 5.0. Costs were calculated using financial healthcare data. Results. A conclusive reference test was performed in 113 children (75%). Sixty-four children (57%) had peanut...
Diagnostic accuracy of Ara h 2 for detecting peanut allergy in children.
Department of Pediatric Pulmonology and Allergology, Wilhelmina Children's Hospital, University Medical Center, Utrecht Lundlaan AB Utrecht, Netherlands. E-mail email@example.com
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Kansen, H. M., Erp, F. C. van, Meijer, Y., Gorissen, D. M. W., Stadermann, M., Velzen, M. F. van, Keusters, W. R., Frederix, G. W. J., Knulst, A. C., Cornelis, K. van der, Thuy-My Le; Diagnostic accuracy of Ara h 2 for detecting peanut allergy in children.. IFIS Food and Health Sciences Database 2022; doi:
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