Objectives. The aim of this study was to evaluate the relationship between β-glucuronidase and androgen levels in overweight and obese women with polycystic ovary syndrome (PCOS). The connection between β-glucuronidase, the abundance of selected gut bacteria, carbohydrate metabolism, and diet quality was also determined. Methods. This cross-sectional study was conducted with 56 women with a mean age of 29.14 ± 5.11 y and a mean body mass index (BMI) of 34.15 ± 5.72kg/m2. Anthropometrical parameters, fecal β-glucosidase activity, and selected food frequency intake were measured. Results. Women with better quality diets, apart from lower BMI and better carbohydrate metabolism parameters, had more abundant Faecalibacterium prausnitzii and Akkermansia muciniphila. Two-hour oral glucose tolerance test (OGTT-2h-glu; mg/dL) was the main predictor of β-glucuronidase activity and there was no relationship between β-glucuronidase activity and androgen levels. Non-Healthy Diet Index-14 (nHDI-14) was the main predictor for A. muciniphila, Bifidobacterium longum...

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