Protective effect of astragaloside IV against pancreatic injury induced by cadmium combined with high fat and high sugar in diabetic mice.

The protective effect of astragaloside IV against pancreatic injury induced by cadmium combined with high fat and high sugar diet in diabetic mice was studied. Diabetic model was established through high fat and high sugar combined with cadmium damage. Mice were randomly divided into a normal group, model group and protective group. After 8 weeks of modeling, the protective group were given different concentrations of astragaloside IV (As-IV) for 4 weeks. The blood glucose content, malondialdehyde (MDA) content, superoxide dismutase (SOD) content and glutathione (GSH) content were determined. Ultra-thin sections of the pancreatic tissue were made and examined under transmission electron microscopy to investigate changes in subcellular structure. The results showed that the MDA content of the model group increased significantly, which was 1.90 times that of normal group (p < 0.01). The contents of SOD and GSH decreased, which were 48.10% (p < 0.01) and 44.40% of...