Recently, the interests about functional ingredients for skin has been increased. Snail mucin has been used to as cosmetic constituent for skin though, the potential of snail mucin for nutricosmetic ingredient has not been fully evaluated. Mucin is a biosynthesized macromolecule which can protect the external damage. The present study investigated the photoprotective effect of the snail mucin against ultraviolet B (UVB)-induced skin photoaging in an animal model. SKH-1 hairless male mice were fed with snail mucin or vehicle for 14 weeks with UVB exposure. Evaluation for the skin damage was analyzed skin replicas, epidermal thickness and collagen fiber integrity, and the moisture contents in the dermal tissue. As well as we studied the effect of snail mucin on the expression of matrix metalloproteinase (MMP)-1/13, hyaluronic acid synthase (HAS) and hyaluronidase (HYAL). The safety of intake of snail mucin is also evaluated in the liver, spleen, and liver damage enzyme...

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