Maternal overnutrition negatively impacts the offspring's health leading to an increased risk of developing chronic diseases or metabolic syndrome in adulthood. What we eat affects the endocannabinoid system (eCS) activity, which in turn modulates lipogenesis and fatty acids utilization in hepatic, muscle, and adipose tissues. This study aimed to evaluate the transgenerational effect of maternal obesity on cannabinoid receptor 1 knock-out (CB1 KO) animals in combination with a postnatal obesogenic diet on the development of metabolic disturbances on their offspring. CB1 KO mice were fed a control diet (CD) or a high-fat diet (HFD; 33% more energy from fat) for 3 months. Offspring born to control and obese mothers were also fed with CD or HFD. We observed that pups born to an HFD-fed mother presented higher postnatal weight, lower hepatic fatty acid amide hydrolase activity, and increased blood cholesterol levels when compared to the offspring born to CD-fed mothers....
Maternal obesity reverses the resistance to LPS-induced adverse pregnancy outcome and increases female offspring metabolic alterations in cannabinoid receptor 1 knockout mice.
J. Aisemberg, Laboratorio de Fisiologia de la Prenez y el Parto, Centro de Estudios Farmacologicos y Botanicos (CEFyBO-UBA/CONICET). Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Piso 16. C1121ABG, Ciudad Autonoma de Buenos Aires, Argentina. E-mail firstname.lastname@example.org
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Bariani, M. V., Correa, F., Rubio, A. P. D., Wolfson, M. L., Schander, J. A., Cella, M., Aisemberg, J., Franchi, A. M.; Maternal obesity reverses the resistance to LPS-induced adverse pregnancy outcome and increases female offspring metabolic alterations in cannabinoid receptor 1 knockout mice.. IFIS Food and Health Sciences Database 2022; doi:
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