Objective. The aim of this study was to investigate the composition of the intestinal microbiota and its association with fecal short chain fatty acids (SCFAs) in children with drug refractory epilepsy (DRE) before and after treatment with a ketogenic diet (KD). Methods. Herein, we conducted a cross-sectional study of 12 children with DRE and 12matched healthy controls to compare the changes in fecal microbiomes and SCFAs. Disease cohort also underwent analysis before and after 6months of KD treatment. Results. A higher microbial alpha diversity and a significant increase in Actinobacteria at the phylum level and Enterococcus, Anaerostipes, Bifidobacterium, Bacteroides, and Blautia at the genus level were observed in the children with DRE. The abundance of the eight epileptic-associated genera was reversed after six months of KD treatment with decreases in Bifidobacterium, Akkermansia, Enterococcaceae and Actinomyces and increases in Subdoligranulum, Dialister, Alloprevotella (...
Gut flora and metabolism are altered in epilepsy and partially restored after ketogenic diets.
Zhen Hong, Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. E-mail email@example.com
- Views Icon Views
- Share Icon Share
- Search Site
Xue Gong, Qianyun Cai, Xu Liu, Dongmei An, Dong Zhou, Rong Luo, Rong Peng, Zhen Hong; Gut flora and metabolism are altered in epilepsy and partially restored after ketogenic diets.. IFIS Food and Health Sciences Database 2022; doi:
Download citation file: