Sulforaphane (SFN) is a sulfur-containing isothiocyanate found in cruciferous vegetables (Brassicaceae) and a well-known activator of nuclear factor-erythroid 2-related factor 2 (Nrf2), considered a master regulator of cellular antioxidant responses. Patients with chronic diseases, such as diabetes, cardiovascular disease, cancer, and chronic kidney disease (CKD) present with high levels of oxidative stress and a massive inflammatory burden associated with diminished Nrf2 and elevated nuclear transcription factor-κB-κB expression. Because it is a common constituent of dietary vegetables, the salutogenic properties of sulforaphane, especially it's antioxidative and anti-inflammatory properties, have been explored as a nutritional intervention in a range of diseases of ageing, though data on CKD remain scarce. In this brief review, the effects of SFN as a senotherapeutic agent are described and a rationale is provided for studies that aim to explore the potential benefits of SFN-rich foods in patients with CKD. ©The Author(s) 2020. Published by Oxford University Press...
Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease.
Unidade de Pesquisa Clinica-UPC, Rua Marques de Parana, 303/4 andar, Federal Fluminense University, Niteroi-Rio de Janeiro 24033-900, Brazil. E-mail firstname.lastname@example.org
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Cardozo, L. F. M. F., Alvarenga, L. A., Ribeiro, M., Lu Dai, Shiels, P. G., Stenvinkel, P., Lindholm, B., Mafra, D.; Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease.. IFIS Food and Health Sciences Database 2022; doi:
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