Irradiation is a reputed efficient sterilizing method that demonstrated valuable effects on meat preservation. This research, based on qualitative untargeted HPLC-Orbitrap metabolomics approach, was intended to estimate the variations in global metabolome profile of irradiated chicken, turkey, and mixed (chicken, turkey, and pork) ground meat to assess the possible presence of a food safety issue concerning the metabolome alteration. Overall, 402 metabolites were identified, and all three matrices exhibited a specific metabolome profile that was not influenced remarkably by the application of five different levels of irradiation intensity. In particular, all three meat categories displayed the following common features: 1) free amino acids pool remained unaffected by irradiation 2) taurine appeared as the most important differentiator for all three category 3) amount of glutathione decreased 4) characteristic although minor, oxidative modifications of polyunsaturated free fatty acids occurred 5) intensified adenosine nucleotide degradation. The presented analytical approach highlighted the usefulness of...

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