The study explores in vitro antifungal and aflatoxin B1 inhibitory potency of chemically characterised Lippia origanoides EO (LOEO) encompassed in chitosan nanoparticle (CS-LOEO-Np). CS-LOEO-Np was physico-chemically characterised through XRD, SEM and FTIR analyses. CS-LOEO-Np exhibited improved antifungal and AFB1 inhibitory efficacy (0.05 and 0.045µlmL-1, respectively) in contrast to LOEO (0.30 and 0.25µlmL-1, respectively). Bioactivity of LOEO loaded nanoparticle was enhanced as reflected by depletion in ergosterol content, rapid cellular ion release and reduced methylglyoxal content. IC50 value equivalent to 4.17µlmL-1 displayed better antioxidant potency of CS-LOEO-Np as compared to LOEO (IC50=6.20µlmL-1). CS-LOEO-Np preserved sensorial attributes of stored Nigella sativa (model food matrix) samples and have higher lethal toxicity dose, that is LD50=8832mgkg-1. Hence, CS-LOEO-Np could serve as novel green candidate to ensure food security with better nutritional and sensorial features. © 2022 Institute of...

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