Butterbur (Petasites japonicus (Siebold & Zucc.) Maxim) leaves are available to consumers in the marketplace, but there is no guarantee that they are safe for human consumption. Previously, we demonstrated that hot water extracts of P. japonicus leaves (KP-1) had anti-inflammatory properties and attenuated memory impairment. However, data regarding KP-1 toxicity are lacking. This study assessed the safety of KP-1 by examining oral and genotoxic effects using in vivo and in vitro tests, respectively. In a single oral dose toxicity and two-week repeated oral dose toxicity study, we observed no toxicologically significant clinical signs or changes in hematology, blood chemistry, and organ weights at any dose during the experiment. Following a thirteen-week repeated oral dose, toxicity, hyperkeratosis, and squamous cell hyperplasia of the limiting ridge in the stomach were observed. The no observable adverse effect level (NOAEL) was found to be 1250 mg/kg/day in male and female rats. However,...
Single and repeated oral dose toxicity and genotoxicity of the leaves of butterbur.
Dae Sik Jang, Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Korea. Tel. +82-2-961-0719. E-mail email@example.com
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Sangsu Park, Jeongin Lim, Kyung Tae Lee, Myung Sook Oh, Dae Sik Jang; Single and repeated oral dose toxicity and genotoxicity of the leaves of butterbur.. IFIS Food and Health Sciences Database 2022; doi:
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