Nigella sativa L. (Ranunculaceae), commonly referred to as black seeds or black cumin, is used in popular medicine (herbal) all over the world for the treatment and prevention of several diseases, including diabetes. This study aims to investigate the inhibitory effect of N. sativa extracts and fractions against the activities of intestinal Î±-glucosidase and pancreatic Î±-amylase in vitro, and to explain the inhibitory effect of these fractions against these enzymes by identifying their active compounds responsible for this effect and determine their modes of inhibition. To do so, N. sativa hexane and acetone extracts were prepared and analyzed by GC-MS and HPLC-DAD, respectively. The hexane extract was further fractioned into eight different fractions, while the acetone extract generated eleven fractions. The extracts as well as the resulting fractions were characterized and evaluated for their potential in vitro antidiabetic activity using intestinal Î±-glucosidase and pancreatic Î±-amylase inhibitory assays in...
Linking the phytochemicals and the α-glucosidase and α-amylase enzyme inhibitory effects of Nigella sativa seed extracts.
Laboratory of Applied Chemistry and Environment (LCAE), Faculty of Sciences Oujda (FSO), University Mohammed First (UMP), Oujda 60000, Morocco. E-mail firstname.lastname@example.org
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Tiji, S., Bouhrim, M., Addi, M., Drouet, S., Lorenzo, J. M., Hano, C., Bnouham, M., Mimouni, M.; Linking the phytochemicals and the α-glucosidase and α-amylase enzyme inhibitory effects of Nigella sativa seed extracts.. IFIS Food and Health Sciences Database 2022; doi:
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