Bioactive compounds from marine macroalgae are gaining immense attention for their application as natural ingredients in various nutraceuticals and food supplements. The present study evaluated the medicinal properties of the organic extracts of four each of brown and red marine macroalgal species, using various in vitro assays. Organic extracts of brown algae of Fucophycidan subclass, such as Sargassum plagiophyllum, Turbinaria decurrens, and red alga Hydropuntia edulis, displayed potential inhibitory properties against antioxidants (IC50 0.2-0.8 mg/mL) and carbolytic enzymes (IC50 0.2-0.9 mg/mL) compared to those exhibited by other studied algae. Noticeably, organic extracts of red alga H. edulis and brown alga T. decurrens could effectively attenuate pro-inflammatory 5-lipoxygenase (IC50 0.4-0.6 mg/mL), thereby demonstrating their potential application to dissuade inflammatory pathogenesis. This study demonstrated the predominantly available brown and red macroalgae as potential marine bioresources to develop functional food candidates. © 2022 Taylor & Francis Group, LLC.