Limited information is available regarding the health-promoting activities of sweetpotato leaves (SPL). The present study investigated antioxidant and anti-inflammatory effects, and phenolic contents in 29 SPL cultivars harvested in 2018 and 2019. Extracts showed total phenolic contents 9.4-23.1 mg gallic acid equivalent/g, and DPPH radical scavenging activity indicated 36.6-247.3 mM of Trolox equivalent/g. SPL extracts were identified to contain bioactive components such as, chlorogenic acid (11.7-22.1 Î¼g/mg), 3,4-dicaffeoylquinic acid (16.3-59.9 Î¼g/mg), 3,5-dicaffeoylquinic acid (50.9-72.7 Î¼g/mg), chlorophyll B (6.1-12.3 Î¼g/mg), lutein (1.9-4.9 Î¼g/mg), chlorophyll A (2.7-4.3 Î¼g/mg) and Î²-carotene (0.1â‰¤Î¼g/mg). RAW 264.7 murine macrophage cells were pretreated with 100-200 Î¼g/mL of SPL extracts and 20 Î¼M of dexamethasone, and inflammation was stimulated by lipopolysaccharide (LPS, 100 ng/mL) treatment for 24 h. In LPS-treated cells, prostaglandin E2 production and COX-2 expression were not downregulated by pretreatment of SPL extracts. However, SPL pretreated cells showed significant suppression of nitric oxide (NO), TNF-Î±, and...
Sweetpotato leaves inhibit lipopolysaccharide-induced inflammation in RAW 264.7 macrophages via suppression of NF-κB signaling pathway.
Sun-Ok Lee, Department of Food Science, University of Arkansas, Fayetteville, AR 72704, USA. E-mail firstname.lastname@example.org
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Hyun-Dong Cho, Brownmiller, C., Harun Sorker, Shahidul Islam, Sun-Ok Lee; Sweetpotato leaves inhibit lipopolysaccharide-induced inflammation in RAW 264.7 macrophages via suppression of NF-κB signaling pathway.. IFIS Food and Health Sciences Database 2022; doi:
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