Lactic acid bacteria (LAB) isolated from kimchi has beneficial antioxidant, anti-obesity, anti-cancer and immunomodulatory effects. Here, we investigated the immunomodulatory effects of vegetable juice (VJ) fermented with Companilactobacillus allii WiKim39 (VJ+ WiKim39) or Lactococcus lactis WiKim0124 (VJ+ WiKim0124) isolated from kimchi, in vitro and in vivo. Nitric oxide (NO) production and levels of inflammatory markers were significantly lower in lipopolysaccharide (LPS)-stimulated RAW264.7 cells treated with heat-inactivated VJ+ WiKim39 and heat-inactivated VJ+ WiKim0124 than in untreated cells (P < 0.05). In mice with dextran sulfate sodium (DSS)-induced colitis, oral administration of VJ+ WiKim39 and VJ+ WiKim0124 attenuated DSS-induced decrease in colon length and mucosal epithelia. Moreover, VJ+ WiKim39 and VJ+ WiKim0124 significantly downregulated several inflammatory markers (P < 0.05). Overall, WiKim39 and WiKim0124 showed immunomodulatory activity in vitro and in vivo and thus, they could be used in health promoting fermented foods. All rights reserved, Elsevier.

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