The involvement of hypoxia-inducible factor-1α (HIF-1α), transforming growth factor-β1 (TGF-β1), Smad and β-catenin signaling pathway in non-alcoholic fatty liver disease (NAFLD) is not fully elucidated. Pioglitazone improves NAFLD, whereas the underlying molecular mechanisms are not extensively clarified. In addition, cranberry and cinnamon have received increasing attention as potential therapeutic agents in metabolic disorders. Hence, this study aimed to test the hypothesis that the downregulation of HIF-1α/TGF-β1/Smad/β-catenin signaling might underlie the pioglitazone effect in HFD-induced liver steatosis in rats. In addition, the study aimed to determine whether the concurrent use of cranberry and/or cinnamaldehyde would boost biochemical and molecular gains of pioglitazone while limiting its significant side effect; weight gain. Rats were kept on a high-fat diet for 14 weeks, and HFD rats were orally treated with pioglitazone, cranberry, or their combinations for 8 weeks. Pioglitazone, cranberry, and to a lesser extent cinnamaldehyde significantly ameliorated the pathological lesions, improved the hepatic...
Skip Nav Destination
Journal Article|
March 10 2022
Boosting effects of cranberry and cinnamaldehyde for pioglitazone amelioration of liver steatosis in rat via suppression of HIF-1α/Smad/β-catenin signaling.
Samar S. Elblehi, Department of Pathology, Faculty of Veterinary Medicine, Alexandria University, Edfina, Behera, Egypt. E-mail samar.saad@alexu.edu.eg
Journal: Journal of Functional Foods
Citation: Journal of Functional Foods (2022) 90
DOI: 10.1016/j.jff.2022.104973
Published: 2022
Citation
Ali, M. A., Mahmoud, S. A., Alkhedaide, A., Soliman, M. M., Al-Shafie, T. A., El-Sayed, Y. S., Shukry, M., Ghamry, H. I., Elblehi, S. S.; Boosting effects of cranberry and cinnamaldehyde for pioglitazone amelioration of liver steatosis in rat via suppression of HIF-1α/Smad/β-catenin signaling.. IFIS Food and Health Sciences Database 2022; doi:
Download citation file:
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Sign in via your Institution
Sign in via your Institution
Analyse Trends
Explore publication trends in the sciences of food and health.
Discover and compare the use of keywords over time.
Find global trends in research through publication categories.