This study aimed to investigate the immunomodulatory effect of edible bird's nest (EBN) in vitro and in vivo studies. EBN-treated peripheral blood mononuclear cells showed that EBN specifically enhanced the expansion of CD3+ T-cells. The restoration of lymphocyte subpopulations under the influence of immunosuppressive drug has been successfully recovered in CD3+ T-cells, not CD45RA+ B-cells and CD335+ NK-cells. In addition, oral administration of EBNs in Sprague-Dawley rats revealed their potential to increase the number of peripheral blood T-cells. Our study also demonstrated that EBN treatments affected the numbers of the Peyer's patches, spleen weight and length, and cellularity of the periarteriolar lymphoid sheath. Interestingly, we observed that elevation of serum interleukin-2 (IL-2) had been correlated with the proliferation of T-cells in the animal model. Therefore, these results are essential for developing therapeutic strategies in improving immunity, particularly T-cell homeostasis, under immunosuppressive therapy. All rights reserved, Elsevier....
The effects of edible bird's nest on T-lymphocyte proliferation, secondary lymphoid organs, and interleukin-2 production.
Sakda Daduang, Protein and Proteomics Research Center for Commercial and Industrial Purposes (ProCCI), Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand. E-mail email@example.com
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Theerawat Dobutr, Wirapong Kantamala, Suphaporn Phimwapi, Nisachon Jangpromma, Patcharaporn Tippayawat, Sophon Boonlue, Jureerut Daduang, Sompong Klaynongsruang, Saowanee Poopornchai, Sakda Daduang; The effects of edible bird's nest on T-lymphocyte proliferation, secondary lymphoid organs, and interleukin-2 production.. IFIS Food and Health Sciences Database 2022; doi:
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