Bovine collagen oligopeptides (BCOP) are small molecule oligopeptides isolated from bovine collagen, which have been proved to modulate the collagen metabolism. However, the effects of BCOP on wound healing is rarely known by public. This study aims to evaluate the beneficial effects of BCOP on wound healing by using an excisional wound model established in mice. Moreover, the role of the PI3K/Akt/mTOR pathway on the migration of fibroblasts in vitro is further elucidated. It was observed that BCOP could significantly reduce the size of the wound area, increasing albumin and prealbumin levels in mice. BCOP could also inhibit the apoptosis, promoting fibroblast proliferation and migration. The mRNA expressions of Collagen I, which have the ability to transform growth factor-Î² 1 (TGF-Î²1) and the hydroxyproline (Hyp) content, were markedly increased after BCOP treatment. The PI3K/Akt/mTOR signaling pathway was also found being activated by BCOP intervention. To summarize, BCOP could accelerate wound...
Bovine collagen oligopeptides accelerate wound healing by promoting fibroblast migration via PI3K/Akt/mTOR signaling pathway.
Yong Li, Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, China. E-mail firstname.lastname@example.org
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Lei Bao, Xiaxia Cai, Mingyuan Zhang, Yang Xiao, Jin Jin, Tong Qin, Yong Li; Bovine collagen oligopeptides accelerate wound healing by promoting fibroblast migration via PI3K/Akt/mTOR signaling pathway.. IFIS Food and Health Sciences Database 2022; doi:
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