Hatakabb is a herbal extract traditionally consumed to ameliorate inflammation from pharynx infections. However, the anti-inflammatory function of Hatakabb was not investigated. This study demonstrated the anti-inflammatory potential, and underlying mechanism of Hatakabb, and its functional ingredient. In LPS-treated macrophages, Hatakabb treatment attenuated TNF-Î± production. A decrease in TNF-Î±, IL-6, and COX-2 expression was detected. In regulatory pathway analysis, Hatakabb suppressed IÎºB-Î± phosphorylation in accordance with a decrease in IÎºB-Î± degradation, and nucleus NF-ÎºB translocation, while enhanced NF-ÎºB phosphorylation. In addition, MAPK phosphorylation was enhanced in association with HMOX-1 upregulation. Our metabolomic analysis showed gallic acid, and pyrogallol contained in the anti-inflammatory subfraction. Compared to gallic acid, pyrogallol strongly diminished TNF-Î± production. Significant changes in inflammatory gene expression, and regulatory protein phosphorylation were responded to pyrogallol in similar to Hatakabb treatment. Our study, for the first time, reveals the anti-inflammatory effect, and mechanism of Hatakabb in which pyrogallol...
Hatakabb, a herbal extract, contains pyrogallol as the novel mediator inhibiting LPS-induced TNF-α production by NF-κB inactivation and HMOX-1 upregulation.
Surapun Tepaamorndech, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathumthani 12120, Thailand. E-mail email@example.com
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Kanittha Chantarasakha, Thiti Asawapanumas, Rinrada Suntivich, Atikorn Panya, Natthaporn Phonsatta, Parameth Thiennimitr, Kobkul Laoteng, Surapun Tepaamorndech; Hatakabb, a herbal extract, contains pyrogallol as the novel mediator inhibiting LPS-induced TNF-α production by NF-κB inactivation and HMOX-1 upregulation.. IFIS Food and Health Sciences Database 2022; doi:
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