Several studies have proposed that cocoa products-enriched in flavonoids reduce anxiety and depressive symptoms. (-)-Epicatechin (Epi), a flavonoid present in high concentration in cocoa, has been associated with many dark chocolate effects and has been postulated as an exercise mimetic. Physical exercise is used as an adjuvant treatment for many depressive patients. This study aimed to evaluate the impact of Epi on resilience in depression-like behavior in a murine model. Male mice were randomly selected and divided into four groups (n=8/group). Beginning at the age of 8-9 weeks, the mice were subjected to Chronic Mild Stress (CMS) and/or treatment Epi for five weeks. Epi was administered by oral gavage twice daily/5 weeks. The control group was housed in conditions without stress and Epi treatment. Depressive behavior was evaluated by sucrose preference and open field tests. Interestingly, Epi reduced anhedonia and anxiogenic behavior in the murine stress model. These...
Epicatechin treatment generates resilience to chronic mild stress-induced depression in a murine model.
R. M. Coral-Vazquez, Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, Instituto Politecnico Nacional, Ciudad de Mexico, Mexico. E-mail firstname.lastname@example.org
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Martinez-Damas, M. G., Genis-Mendoza, A. D., Cruz, V. P. de la, Canela-Tellez, G. D., Jimenez-Estrada, I., Nicolini-Sanchez, J. H., Ramos-Chavez, L. A., Garcia, S., Ramirez-Ramirez, M., Coral-Vazquez, R. M.; Epicatechin treatment generates resilience to chronic mild stress-induced depression in a murine model.. IFIS Food and Health Sciences Database 2022; doi:
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