The world wine culture prevails, and the problem of the alcohol injury to people is more and more serious. The intervention effect of different probiotic strains on alcohol injury need to be evaluated. During the experiment period, ICR mice were given 50% ethanol by intragastric gavage, and were divided into groups with Lactobacillus plantarum Zhang-LL (1.0×107 CFU/d in low-dose group, 1.0×109 CFU/d in high-dose group) and its culture supernatant to intervention. After 12 weeks of intervention, the alleviating effect of Lactobacillus plantarum. Zhang-LL on the negative effects of long-term alcohol intake and body weight was evaluated. The results showed as follows: Lactobacillus plantarum Zhang-LL intervention could significantly alleviate the reducing of food intake and inhibited weight addition (P<0.05); Compared with the model group, the supernatant of Lactobacillus plantarum Zhang-LL significantly reduced the levels of triglyceride and low density lipoprotein cholesterol in serum, increased the content of glutathione...

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