Diabetes-induced cardiomyocyte apoptosis is one of the major causes of mortality in patients with diabetes. Numerous studies have indicated the beneficial effects of Lactobacillus reuteri GMNL-263. However, the protective effect of Lactobacillus reuteri GMNL-263 in cardiac damage associated with diabetes remains poorly understood. In this study, we aimed to investigate the protective effect of Lactobacillus reuteri GMNL-263 on cardiomyocytes in diabetic rats. Five-week-old male Wistar rats were categorized into normal control group, diabetes group (55 mg/kgw STZ-induced diabetes via intraperitoneal injection), and diabetic animals treated with Lactobacillus reuteri GMNL-263 (109 CFU/rat/day, oral administration for 4 weeks). The results were presented that oral administration of a high dose of Lactobacillus reuteri GMNL-263 in diabetic rats activated IGF1R cell survival pathways to decrease the Fas-dependent and mitochondrial-dependent apoptotic pathways induced by hyperglycemia. We found that GMNL-263 significantly attenuated cell apoptosis via the IGF1R survival pathway in diabetic rats. The findings of...
Hyperglycemia-induced cardiac damage is alleviated by heat-inactivated Lactobacillus reuteri GMNL-263 via activation of the IGF1R survival pathway.
Chih-Yang Huang, Department of Anesthesia, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan. E-mail firstname.lastname@example.org
- Views Icon Views
- Share Icon Share
- Search Site
Ker-Ping Koay, Chi-Kang Tsai,, B., Chia-Hua Kuo, Wei-Wen Kuo, Hsiang-Ning Luk, Cecilia Hsuan Day, Ray-Jade Chen, Michael Yu-Chih Chen, Vijaya Padma, V., Chih-Yang Huang; Hyperglycemia-induced cardiac damage is alleviated by heat-inactivated Lactobacillus reuteri GMNL-263 via activation of the IGF1R survival pathway.. IFIS Food and Health Sciences Database 2022; doi:
Download citation file: