Studies have shown that the intracellular content of probiotic (postbiotics) has antioxidant properties, which can improve the antioxidant status in vivo. However, its absorption and mechanisms underlying the protective effects are still unknown. The antioxidant capacity of Lacticaseibacillus casei CRL431 (IC-431) postbiotics was determined after an in vitro simulated digestive process. Permeability of antioxidant constituents of IC-431 was determined by an ex vivo everted duodenum assay. Aflatoxin B1-induced oxidative stress rat models were established and treated with IC-431; biomarkers of hepatic mitochondrial function and H2O2 levels, oxidative stress, and oxidative stress index (OSi) were examined. The antioxidant capacity of IC-431 (477Â±45.25 Î¼mol Trolox Equivalent/L) was reduced by exposure to the simulated digestive process. No difference (p > 0.05) was found among digested and the permeate fraction of IC-431. A protective effect was observed by significantly lower OSi and higher liver glutathione peroxidase and catalase...
Protective effect of Lacticaseibacillus casei CRL 431 postbiotics on mitochondrial function and oxidative status in rats with aflatoxin B1-induced oxidative stress.
A. Hernandez-Mendoza, Laboratorio de Quimica y Biotecnologia de Productos Lacteos, Centro de Investigacion en Alimentacion y Desarrollo A.C., Carretera Gustavo Enrique Astiazaran Rosas, No. 46 Col. La Victoria, 83304, Hermosillo, Sonora, Mexico. E-mail firstname.lastname@example.org
Guerrero-Encinas, I., Gonzalez-Gonzalez, J. N., Santiago-Lopez, L., Muhlia-Almazan, A., Garcia, H. S., Mazorra-Manzano, M. A., Vallejo-Cordoba, B., Gonzalez-Cordova, A. F., Hernandez-Mendoza, A.; Protective effect of Lacticaseibacillus casei CRL 431 postbiotics on mitochondrial function and oxidative status in rats with aflatoxin B1-induced oxidative stress.. IFIS Food and Health Sciences Database 2022; doi:
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