Aims. To compare the heat stability of two globally prevalent human norovirus (HuNoV) strains (GII. 2 [P16] and GII. 4 [P16]) and a commonly used HuNoV surrogate, tulane virus (TV). Methods and Results. With the use of a newly developed zebrafish larvae platform, we measured the change of infectivity of HuNoV GII. 2 [P16] and GII. 4 [P16] toward mild heat treatment at 55 °C for 5 min. TV was tested with the same experimental design. As a result, the virus infectivity measurement clearly indicated the higher heat resistance of HuNoV GII. 2 [P16] (no reduction) than GII. 4 [P16] (>0.8-log TCID50 ml-1 reduction) and TV (2.5-log TCID50 ml-1 reduction). Further exploration revealed higher virus structural stability of HuNoV GII. 2 than GII. 4 strains by the use of different clinical samples with different evaluation methods. Conclusion. The inactivation data generated from the surrogate virus TV...
The globally re-emerging norovirus GII.2 manifests higher heat resistance than norovirus GII.4 and Tulane virus.
Dan Li, Department of Food Science & Technology, Faculty of Science, National University of Singapore, Singapore, Singapore. E-mail email@example.com
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Turk Hsern Tan, M., Liang Xue, Dapeng Wang, Gorji, M. E., Yan Li, Zhiyuan Gong, Dan Li; The globally re-emerging norovirus GII.2 manifests higher heat resistance than norovirus GII.4 and Tulane virus.. IFIS Food and Health Sciences Database 2022; doi:
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